I recommend setting AutoPilot Mode Cron Check Frequency to 15 minutes if this site is still in early development stages where new plugins are going to be added removed or the site will always be in flux. If the site is established then typically plugins will not be added or removed on a regular basis and then I would recommend either turning AutoPilot Mode On or Off as needed or possibly doing a 30 minute interval on the Cron Check.
Thanks again
–Ed