Judging by the help info on the site I think the only problem would be that HipHop Virtual Machine does not support any of the Apache server htaccess directives or it uses its own rewrite method that does not have anything to do with Apache htaccess code/rules/files. I only quickly looked around the Internet, but I get the sense that you would use HHVM in a similar way you would use Nginx or an Nginx Reverse Proxy. Something like this: use apache/nginx at the front-end and proxy to the HipHop server.
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